Research on the changes of ocular surface microorganisms in meibomian gland dysfunction patients

doi:10.3760/ cma.j.issn.1673-5803.2022.04.006

International Review of Ophthalmology ›› 2022, Vol. 46 ›› Issue (4): 324-327.doi: 10.3760/ cma.j.issn.1673-5803.2022.04.006

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Research on the changes of ocular surface microorganisms in meibomian gland dysfunction patients

Bao Zhengyilin^1,2, Zhang Wenjia^1,2, Huang Yue ^1,2, Hu Zhulin²

¹Kunming Medical University, Kunming 650000, China;²Department of Ophthalmology, Affiliated Hospital of Yunnan University, Kunming 650000, China

Received:2021-10-25 Online:2022-08-22 Published:2022-08-22
Contact: Hu Zhulin, Email: hzl@263.net
Supported by:
Applied Basic Research Joint Project of Kunming Medical University (202001AY070001-255); Medical Leading Talents Training Plan of Yunnan Health Commission(L-2019029)

Abstract

Abstract: Meibomian gland dysfunction (MGD) is closely related to ocular surface microorganisms. The changes in the species and quantity of ocular surface microorganisms are the inducement or aggravating factors of MGD. There are many potential pathogenic strains on the ocular surface in MGD patients, such as coagulate negative staphylococcus, propionibacterium acnes, and corynebacterium and so on. The strong immune escape and toxicity of ocular surface microorganisms affect the immune response of MGD patients. In addition, the microorganisms on the eye surface have lipase and protease activities, which affect the secretion and anti-inflammatory response of eyelid fat in meibomian gland, and aggravate the condition of MGD patients.(Int Rev Ophthalmol, 2022, 46: 324-327)

Key words: Meibomian gland dysfunction, microbiome, pathogen, bacteria flora

Bao Zhengyilin Zhang Wenjia Huang Yue Hu Zhulin. Research on the changes of ocular surface microorganisms in meibomian gland dysfunction patients[J]. International Review of Ophthalmology, 2022, 46(4): 324-327.

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Research on the changes of ocular surface microorganisms in meibomian gland dysfunction patients

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